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Palladium-catalyzed oxidative C-H/C-H cross-coupling of pyrazolo[1,5- a ]azines with five-membered heteroarenes.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Jan 18; Vol. 58 (6), pp. 827-830. Date of Electronic Publication: 2022 Jan 18. - Publication Year :
- 2022
-
Abstract
- The use of Pd(OAc) <subscript>2</subscript> as the catalyst and AgOAc as the oxidant enabled the direct regioselective oxidative C-H/C-H cross-coupling of pyrazolo[1,5- a ]pyrimidines or pyrazolo[1,5- a ]pyridines with various five-membered heteroarenes without the need of pre-activation and/or directing groups. Successful coupling partners include thiophenes, benzothiophenes, thiazoles, furans, oxazoles, indoles and imidazo[1,2- a ]pyridines.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 58
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34931645
- Full Text :
- https://doi.org/10.1039/d1cc06337e