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Transmission of NDM-5-Producing and OXA-48-Producing Escherichia coli Sequence Type 648 by International Visitors without Previous Medical Exposure.
- Source :
-
Microbiology spectrum [Microbiol Spectr] 2021 Dec 22; Vol. 9 (3), pp. e0182721. Date of Electronic Publication: 2021 Dec 22. - Publication Year :
- 2021
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Abstract
- Carbapenemase-producing Escherichia coli sequence type (ST) 648 strains were isolated from two international visitors without previous medical exposure from Southeast Asian countries in a hospital in Japan. One isolate, FUJ80154, carried bla <subscript>NDM-5</subscript> in a complex class 1 integron on an IncFIB/FII plasmid; the other isolate, FUJ80155, carried two copies of bla <subscript>OXA-48</subscript> on the chromosome flanked by IS 1R on both sides. The core-genome based-phylogenetic analysis with publicly available genome data of E. coli ST648 carrying bla <subscript>NDM-5</subscript> or bla <subscript>OXA-48-like</subscript> demonstrated high genetic similarity between FUJ80154 and NDM-5-prooducing E. coli ST648 strains isolated in South and Southeast Asian countries. On the other hand, no closely related isolates of FUJ80155 were identified. In the absence of prior hospitalization overseas, neither patient had qualified for routine screening of multidrug-resistant organisms, and the isolates were incidentally identified in cultures ordered at the discretion of the treating physician. IMPORTANCE Although patients with history of international hospitalization are often subject to screening for multidrug-resistant organisms, it is unclear whether patients who reside in countries where carbapenemase-producing Enterobacterales (CPE) is endemic but have no history of local hospitalization contribute to the transmission of CPE. In this study, NDM-5-producing and OXA-48-producing Escherichia coli sequence type (ST) 648, a recently recognized high-risk, multidrug-resistant clone, were detected from two overseas visitors without previous medical exposure. The findings of this study suggest that active surveillance culture on admission to hospital may be considered for travelers from countries with endemicity of carbapenem-resistant organisms even without history of local hospitalization and underscore the need to monitor cross-border transmission of high-risk clones, such as carbapenemase-producing E. coli ST648.
- Subjects :
- Bacterial Proteins metabolism
Carbapenem-Resistant Enterobacteriaceae genetics
Carbapenem-Resistant Enterobacteriaceae isolation & purification
Drug Resistance, Multiple, Bacterial genetics
Emigrants and Immigrants
Environmental Exposure
Escherichia coli drug effects
Escherichia coli isolation & purification
Humans
Japan
Plasmids genetics
beta-Lactamases metabolism
Bacterial Proteins genetics
Escherichia coli genetics
Escherichia coli Infections transmission
Escherichia coli Proteins genetics
Tourism
beta-Lactamases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2165-0497
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Microbiology spectrum
- Publication Type :
- Academic Journal
- Accession number :
- 34937178
- Full Text :
- https://doi.org/10.1128/spectrum.01827-21