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N-terminal pro-brain natriuretic peptide and adverse outcomes in Chinese patients with hypertrophic cardiomyopathy.
- Source :
-
Bioscience reports [Biosci Rep] 2022 Jan 28; Vol. 42 (1). - Publication Year :
- 2022
-
Abstract
- Background: Although numerous studies have suggested that elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) is positively correlated with cardiovascular events, especially the heart failure and heart failure-related death (HFRD), evidence of the association between NT-proBNP and the adverse outcomes of hypertrophic cardiomyopathy (HCM) is still relatively limited. The present study was performed to evaluate the relationship between NT-proBNP and outcomes in patients with HCM.<br />Methods: Observational cohort methodology was used in the present study, and a total of 227 patients were included. And the patients were followed for 44.97 ± 16.37 months. Patients were categorized into three groups according to these NT-proBNP tertiles: first tertile (≤910 pg/ml, n=68), second tertile (913-2141 pg/ml, n=68), and third tertile (≥2151 pg/ml, n=69). The adverse outcomes of the present study were all-cause death (ACD) and cardiac death (CD).<br />Results: According to the risk category of NT-proBNP, the incidence of ACD (P=0.005) and CD (P=0.032) among the three groups showed significant differences. Multivariate Cox regression analysis suggested that the ACD and CD in the third tertile have 7.022 folds (hazard risk [HR] = 7.022 [95% confidence interval [CI]: 1.397-35.282], P=0.018) and 7.129 folds (HR = 7.129 [95% CI: 1.329-38.237], P=0.022) increased risks as compared with those in the first tertile. Kaplan-Meier survival analyses showed that the cumulative risks of ACD and CD in patients with HCM tended to increase.<br />Conclusion: The present study indicated NT-proBNP was a novel biomarker suitable for predicting adverse prognosis in patients with HCM, which may be used for early recognition and risk stratification.<br /> (© 2022 The Author(s).)
- Subjects :
- Adult
Aged
Asian People
Biomarkers blood
Cardiomyopathy, Hypertrophic diagnosis
Cardiomyopathy, Hypertrophic ethnology
Cardiomyopathy, Hypertrophic mortality
Cause of Death
China epidemiology
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Time Factors
Cardiomyopathy, Hypertrophic blood
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4935
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioscience reports
- Publication Type :
- Academic Journal
- Accession number :
- 34940836
- Full Text :
- https://doi.org/10.1042/BSR20212098