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The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 13; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 13. - Publication Year :
- 2021
-
Abstract
- Glioblastomas (GBMs) are complex ecosystems composed of highly multifaceted tumor and myeloid cells capable of responding to different environmental pressures, including therapies. Recent studies have uncovered the diverse phenotypical identities of brain-populating myeloid cells. Differences in the immune proportions and phenotypes within tumors seem to be dictated by molecular features of glioma cells. Furthermore, increasing evidence underscores the significance of interactions between myeloid cells and glioma cells that allow them to evolve in a synergistic fashion to sustain tumor growth. In this review, we revisit the current understanding of glioma-infiltrating myeloid cells and their dialogue with tumor cells in consideration of their increasing recognition in response and resistance to immunotherapies as well as the immune impact of the current chemoradiotherapy used to treat gliomas.
- Subjects :
- Brain pathology
Brain Neoplasms pathology
Cell Line, Tumor
Glioblastoma immunology
Glioblastoma therapy
Glioma pathology
Humans
Immunotherapy methods
Immunotherapy trends
Macrophages physiology
Microglia pathology
Myeloid Cells immunology
Myeloid Cells metabolism
Myeloid Cells pathology
Neoplastic Stem Cells pathology
Neoplastic Stem Cells physiology
Phenotype
Tumor Microenvironment immunology
Glioblastoma pathology
Macrophages immunology
Microglia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34948178
- Full Text :
- https://doi.org/10.3390/ijms222413382