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Chemoselective Synthesis of Sulfenylated Spiroindolenines from Indolyl-ynones via Organosulfenyl Chloride-Mediated Dearomatizing Spirocyclization.
- Source :
-
Organic letters [Org Lett] 2022 Jan 14; Vol. 24 (1), pp. 390-394. Date of Electronic Publication: 2021 Dec 29. - Publication Year :
- 2022
-
Abstract
- A metal-free sulfenylation/spirocyclization of indolyl-ynones realized by organosulfenyl chloride, generated in situ from the reaction of disulfides and PhICl <subscript>2</subscript> , is presented. This cascade one-pot process enables a chemoselective synthesis of diverse sulfenylated spiroindolenines depending on the substituent pattern at the two-position of indolyl-ynones.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 34964636
- Full Text :
- https://doi.org/10.1021/acs.orglett.1c04063