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Recapitulating human myogenesis ex vivo using human pluripotent stem cells.
- Source :
-
Experimental cell research [Exp Cell Res] 2022 Feb 15; Vol. 411 (2), pp. 112990. Date of Electronic Publication: 2021 Dec 30. - Publication Year :
- 2022
-
Abstract
- Human pluripotent stem cells (hPSCs) provide a human model for developmental myogenesis, disease modeling and development of therapeutics. Differentiation of hPSCs into muscle stem cells has the potential to provide a cell-based therapy for many skeletal muscle wasting diseases. This review describes the current state of hPSCs towards recapitulating human myogenesis ex vivo, considerations of stem cell and progenitor cell state as well as function for future use of hPSC-derived muscle cells in regenerative medicine.<br /> (Published by Elsevier Inc.)
- Subjects :
- Cell Differentiation physiology
Humans
Models, Biological
Muscle Development genetics
Muscle, Skeletal cytology
Muscle, Skeletal physiology
Myoblasts, Skeletal cytology
Myoblasts, Skeletal physiology
PAX7 Transcription Factor genetics
PAX7 Transcription Factor metabolism
Satellite Cells, Skeletal Muscle cytology
Satellite Cells, Skeletal Muscle physiology
Muscle Development physiology
Pluripotent Stem Cells cytology
Pluripotent Stem Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2422
- Volume :
- 411
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental cell research
- Publication Type :
- Academic Journal
- Accession number :
- 34973262
- Full Text :
- https://doi.org/10.1016/j.yexcr.2021.112990