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Polysaccharide from edible alga Gloiopeltis furcata attenuates intestinal mucosal damage by therapeutically remodeling the interactions between gut microbiota and mucin O-glycans.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2022 Feb 15; Vol. 278, pp. 118921. Date of Electronic Publication: 2021 Nov 30. - Publication Year :
- 2022
-
Abstract
- Gloiopeltis furcata is an edible alga that has long been consumed in China. However, the bioactive polysaccharides from G. furcata have been largely unexplored. Here, we show for the first time that a sulfated polysaccharide from G. furcata (SAO) could improve the integrity of the colonic epithelial layer and protect against dextran sulfate sodium-induced intestinal mucosal damage. Mechanistically, SAO attenuated colonic mucosal damage by therapeutically remodeling the interactions between gut microbiota and mucin O-glycans. Specifically, SAO increased the proportions of complex long-chain mucin O-glycans in the epithelial layer with two terminal N-acetylneuraminic acid residues and promoted the growth of probiotic bacteria including Roseburia spp. and Muribaculaceae. Altogether, our study demonstrates a novel application of SAO for the treatment of inflammatory bowel disease-associated mucosal damage and forms the basis to understand the therapeutic effects of natural polysaccharides from the perspective of symbiotic interactions between host mucin O-glycome and gut microbiome.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Bacteria drug effects
Carbohydrate Conformation
Dextran Sulfate
Microbial Sensitivity Tests
Mucins chemistry
Polysaccharides chemistry
Polysaccharides isolation & purification
Anti-Bacterial Agents pharmacology
Gastrointestinal Microbiome drug effects
Intestinal Mucosa drug effects
Mucins pharmacology
Polysaccharides pharmacology
Seaweed chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 278
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 34973740
- Full Text :
- https://doi.org/10.1016/j.carbpol.2021.118921