Back to Search Start Over

CEFOVECIN PROTEIN BINDING AS A PREDICTOR FOR EXTENDED DURATION OF ACTION: A REVIEW OF CURRENT LITERATURE AND IN VITRO ANALYSIS IN MULTIPLE ZOOLOGICAL SPECIES.

Authors :
Valitutto MT
Yu JH
Raphael BL
Calle PP
Sykes JM
Paré J
Moore RP
Papich MG
Source :
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians [J Zoo Wildl Med] 2021 Dec; Vol. 52 (4), pp. 1185-1194.
Publication Year :
2021

Abstract

Cefovecin is a third-generation cephalosporin antibiotic with an efficacy of 2 wk following a single injection in domestic dogs and cats. A high degree of plasma protein binding to cefovecin has been proposed as one of the mechanisms responsible for the long elimination half-life, but protein binding has not been evaluated extensively in nondomestic species. In this study, a review of the current literature was conducted, and pharmacokinetic data were compiled for species in which cefovecin has been evaluated thus far. Additionally, in vitro cefovecin protein binding was evaluated in plasma from 22 nondomestic species representing a broad range of taxa. Animals of the order Carnivora demonstrated protein-binding levels of >98%, which is supportive of the long elimination half-life seen in related species. Protein binding was highly variable in Artiodactyl and Perissodactyl species, with dolphins ( Tursiops truncatus ) and barasingha ( Rucervus duvaucelii ) displaying high protein binding (99.12% to >99%), but not gazelles ( Eudorcas thomsonii ) or equids (91.76-92.70%). Cefovecin was not highly bound in any reptiles or birds, corresponding to short half-lives reported for these taxa. These results suggest that a high percentage of plasma protein binding in vitro may predict in which species cefovecin may exhibit a long half-life and duration of action in vivo. These findings may aid in selecting species for cefovecin pharmacokinetic research and for empirical treatment of infections caused by susceptible bacteria.

Details

Language :
English
ISSN :
1042-7260
Volume :
52
Issue :
4
Database :
MEDLINE
Journal :
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
Publication Type :
Academic Journal
Accession number :
34998288
Full Text :
https://doi.org/10.1638/2021-0068