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Tunable NIR Absorption Property of a Dithiolene Nickel Complex: A Promising NIR-II Absorption Material for Photothermal Therapy.
- Source :
-
ACS applied bio materials [ACS Appl Bio Mater] 2021 May 17; Vol. 4 (5), pp. 4406-4412. Date of Electronic Publication: 2021 Apr 22. - Publication Year :
- 2021
-
Abstract
- Exogenous photothermal agents absorbing in the second near-infrared optical window (NIR-II, 1000-1700 nm) have received much attention due to their use in noninvasive photothermal therapy. A small quantity of organic NIR-II photothermal agents have been exploited, and the development of organic NIR-II photothermal materials is an urgent need for biological applications. In this study, we designed and synthesized three dithiolene nickel(II) complexes with different ligands-bis(phenyl) dithiolene for NiBD-Ph, bis(fluorenyl) dithiolene for NiBD-Fl, and bis(carbazolyl) dithiolene for NiBD-Cz-and investigated their photophysical properties. These complexes exhibited ligand-dependent NIR absorption performance, centered at 854 nm for NiBD-Ph, 942 nm for NiBD-Fl, and 1010 nm for NiBD-Cz, respectively. NiBD-Cz is wrapped in ethylene oxide/propylene oxide block copolymer (F-127) through a hydrophilic-hydrophobic interaction to form water-soluble NiBD-Cz/F-127 nanoparticles (NiBD-Cz NPs), and the absorption peak of NiBD-Cz NPs are red-shifted to 1036 nm. NiBD-Cz NPs exhibit good dispersibility in water, robust photostability, and a high photothermal conversion efficiency (PCE) of 63.6% under 1064 nm laser irradiation, which is the highest PCE among metal bis(dithiolene) complexes up to now. The high PCE makes it possible to achieve better photothermal treatment effects even at low concentrations and under low-power laser irradiation.
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Biocompatible Materials chemical synthesis
Biocompatible Materials chemistry
Cell Proliferation drug effects
Cell Survival drug effects
Coordination Complexes chemical synthesis
Coordination Complexes chemistry
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Infrared Rays
Materials Testing
Molecular Structure
Nickel chemistry
Particle Size
Photothermal Therapy
Sulfhydryl Compounds chemistry
Antineoplastic Agents pharmacology
Biocompatible Materials pharmacology
Coordination Complexes pharmacology
Nickel pharmacology
Sulfhydryl Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2576-6422
- Volume :
- 4
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- ACS applied bio materials
- Publication Type :
- Academic Journal
- Accession number :
- 35006852
- Full Text :
- https://doi.org/10.1021/acsabm.1c00168