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PDA-Based Glyconanomicelles for Hepatocellular Carcinoma Cells Active Targeting Via Mannose and Asialoglycoprotein Receptors.
- Source :
-
ACS applied bio materials [ACS Appl Bio Mater] 2021 Jun 21; Vol. 4 (6), pp. 4789-4799. Date of Electronic Publication: 2021 Jun 07. - Publication Year :
- 2021
-
Abstract
- Hepatocellular carcinoma (HCC) is the sixth most common neoplasia and the fourth most common cause of cancer-related mortality worldwide. Sorafenib is the first-line molecular therapy for patients in an advanced stage of HCC. However, the recommended clinical dose of Sorafenib is associated with several complications, which derive from its lack of cell specificity and its very low water solubility. To circumvent these drawbacks, in the present study we developed two sugar-coated polydiacetylene-based nanomicelles-Sorafenib carriers targeting mannose and asialoglycoprotein receptors (MR and ASGPR, respectively). The strategies allowed the inducement of apoptosis and reduction of cell proliferation at a nanomolar, instead of micromolar, range in liver cancer cells. The study showed that, contrary to literature data, Sorafenib included into the pMicMan (Man = mannose) vector (targeting MR) is more efficient than pMicGal (Gal = galactose) (targeting ASGPR). Indeed, pMicMan increased the endosomal incorporation with an increased intracellular Sorafenib concentration that induced apoptosis and reduced cell proliferation at a low concentration range (10-20 nM).
- Subjects :
- Antineoplastic Agents chemistry
Apoptosis drug effects
Asialoglycoprotein Receptor metabolism
Carcinoma, Hepatocellular metabolism
Cell Proliferation drug effects
Endosomes metabolism
Galactose chemistry
Hep G2 Cells
Humans
Liver Neoplasms metabolism
Mannose chemistry
Mannose Receptor metabolism
Micelles
Nanoparticles chemistry
Polyacetylene Polymer chemistry
Sorafenib chemistry
Antineoplastic Agents administration & dosage
Carcinoma, Hepatocellular drug therapy
Galactose administration & dosage
Liver Neoplasms drug therapy
Mannose administration & dosage
Nanoparticles administration & dosage
Polyacetylene Polymer administration & dosage
Sorafenib administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2576-6422
- Volume :
- 4
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ACS applied bio materials
- Publication Type :
- Academic Journal
- Accession number :
- 35007028
- Full Text :
- https://doi.org/10.1021/acsabm.0c01679