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Single-Atom Gadolinium Anchored on Graphene Quantum Dots as a Magnetic Resonance Signal Amplifier.
- Source :
-
ACS applied bio materials [ACS Appl Bio Mater] 2021 Mar 15; Vol. 4 (3), pp. 2798-2809. Date of Electronic Publication: 2021 Mar 04. - Publication Year :
- 2021
-
Abstract
- A single-atom metal doped on carbonaceous nanomaterials has attracted increasing attention due to its potential applications as high-performance catalysts. However, few studies focus on the applications of such nanomaterials as nanotheranostics for simultaneous bioimaging and cancer therapy. Herein, it is pioneeringly demonstrated that the single-atom Gd anchored onto graphene quantum dots (SAGd-GQDs), with dendrite-like morphology, was successfully prepared. More importantly, the as-fabricated SAGd-GQDs exhibits a robustly enhanced longitudinal relaxivity ( r <subscript>1</subscript> = 86.08 mM <superscript>-1</superscript> s <superscript>-1</superscript> ) at a low Gd <superscript>3+</superscript> concentration of 2 μmol kg <superscript>-1</superscript> , which is 25 times higher than the commercial Gd-DTPA ( r <subscript>1</subscript> = 3.44 mM <superscript>-1</superscript> s <superscript>-1</superscript> ). In vitro and in vivo studies suggest that the obtained SAGd-GQDs is a highly potent and contrast agent to obtain high-definition MRI, thereby opening up more opportunities for future precise clinical theranostics.
Details
- Language :
- English
- ISSN :
- 2576-6422
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- ACS applied bio materials
- Publication Type :
- Academic Journal
- Accession number :
- 35014319
- Full Text :
- https://doi.org/10.1021/acsabm.1c00030