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Olive oil intake and cancer risk: A systematic review and meta-analysis.
- Source :
-
PloS one [PLoS One] 2022 Jan 11; Vol. 17 (1), pp. e0261649. Date of Electronic Publication: 2022 Jan 11 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Background: Research evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis.<br />Methods: A systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed.<br />Results: 45 studies were included in the meta-analysis; 37 were case-control (17,369 cases and 28,294 controls) and 8 were cohort studies (12,461 incident cases in a total cohort of 929,771 subjects). Highest olive oil consumption was associated with 31% lower likelihood of any cancer (pooled RR = 0.69, 95%CI: 0.62-0.77), breast (RR = 0.67, 95%CI: 0.52-0.86), gastrointestinal (RR = 0.77, 95%CI: 0.66-0.89), upper aerodigestive (RR = 0.74, 95%CI: 0.60-0.91) and urinary tract cancer (RR = 0.46, 95%CI: 0.29-0.72). Significant overall effects spanned both Mediterranean and non-Mediterranean participants, studies presenting a multivariate and a univariate analysis and all subgroups by study quality.<br />Conclusions: Olive oil consumption seems to exert beneficial actions in terms of cancer prevention. Additional prospective cohort studies on various cancer types and survivors, as well as large randomized trials, seem desirable.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Breast Neoplasms pathology
Breast Neoplasms prevention & control
Case-Control Studies
Databases, Factual
Female
Gastrointestinal Neoplasms pathology
Gastrointestinal Neoplasms prevention & control
Humans
Neoplasms pathology
Risk Factors
Urologic Neoplasms pathology
Urologic Neoplasms prevention & control
Neoplasms prevention & control
Olive Oil administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 35015763
- Full Text :
- https://doi.org/10.1371/journal.pone.0261649