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A model-based approach to designing developmental toxicology experiments using sea urchin embryos.
- Source :
-
Archives of toxicology [Arch Toxicol] 2022 Mar; Vol. 96 (3), pp. 919-932. Date of Electronic Publication: 2022 Jan 13. - Publication Year :
- 2022
-
Abstract
- The key aim of this paper is to suggest a more quantitative approach to designing a dose-response experiment, and more specifically, a concentration-response experiment. The work proposes a departure from the traditional experimental design to determine a dose-response relationship in a developmental toxicology study. It is proposed that a model-based approach to determine a dose-response relationship can provide the most accurate statistical inference for the underlying parameters of interest, which may be estimating one or more model parameters or pre-specified functions of the model parameters, such as lethal dose, at maximal efficiency. When the design criterion or criteria can be determined at the onset, there are demonstrated efficiency gains using a more carefully selected model-based optimal design as opposed to an ad-hoc empirical design. As an illustration, a model-based approach was theoretically used to construct efficient designs for inference in a developmental toxicity study of sea urchin embryos exposed to trimethoprim. This study compares and contrasts the results obtained using model-based optimal designs versus an ad-hoc empirical design.<br /> (© 2022. The Author(s).)
- Subjects :
- Animals
Anti-Infective Agents administration & dosage
Anti-Infective Agents toxicity
Dose-Response Relationship, Drug
Embryo, Nonmammalian drug effects
Sea Urchins
Trimethoprim administration & dosage
Embryonic Development drug effects
Research Design
Toxicology methods
Trimethoprim toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0738
- Volume :
- 96
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 35022802
- Full Text :
- https://doi.org/10.1007/s00204-021-03201-1