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Subgroup analysis reveals higher reliability of the new comprehensive evaluation of Global Initiative for Chronic Obstructive Lung Disease 2019.
- Source :
-
Scientific reports [Sci Rep] 2022 Jan 14; Vol. 12 (1), pp. 757. Date of Electronic Publication: 2022 Jan 14. - Publication Year :
- 2022
-
Abstract
- To estimate the severity of the disease in outpatients with chronic obstructive pulmonary disease (COPD) in Hunan Province, China and use the subgroup analysis to evaluate the reliability of the new comprehensive evaluation of Global Initiative for Chronic Obstructive Lung Disease (GOLD). COPD outpatients from 12 medical centers in Hunan Province, China were stratified into groups A-D, and group D patients were further stratified into subgroups D <subscript>1</subscript> -D <subscript>3</subscript> according to the GOLD 2016 and 2019 comprehensive assessment. Demography, clinical characteristics and medications were compared among groups. In 1017 COPD outpatients, the distribution from group A to D and subgroup D <subscript>1</subscript> to D <subscript>3</subscript> was 41 (4.0%), 249 (24.5%), 17 (1.7%), 710 (69.8%) and 214 (30.2%), 204 (28.7%), 292 (41.1%), according to GOLD 2016. In terms of demographic and clinical characteristics related to A-D groups, there was a significant difference in COPD assessment test (CAT), modified Medical British Research Council (mMRC), the clinical COPD questionnaire(CCQ), age, BMI, education level, smoking history, comorbidities, the course of chronic bronchitis/emphysema, number of exacerbations/hospitalisations in the previous year, treatment protocols, forced expiratory volume in one second (FEV1) % predicted, and FEV1/forced vital capacity (FVC) (pā<ā0.01). Furthermore, some patients in groups C-D regrouped to groups A-B were all C <subscript>1</subscript> and D <subscript>1</subscript> subgroups according to GOLD 2019. Comparing subgroup D <subscript>1</subscript> with group B, subgroup D <subscript>2</subscript> and subgroup D <subscript>3</subscript> , it was found that the demography, clinical characteristics and medications of subgroup D <subscript>1</subscript> were the closest to group B, according to GOLD 2016 (pā<ā0.01). The disease severity of outpatients with COPD in Hunan Province was more pronounced in group B and D and patients in groups A-D had different demography, clinical characteristics and medications. Subgroup analysis can explain to a certain extent that GOLD2019's new comprehensive assessment is more reliable than GOLD 2016.<br /> (© 2022. The Author(s).)
- Subjects :
- Aged
China
Cross-Sectional Studies
Female
Forced Expiratory Volume
Humans
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive classification
Pulmonary Disease, Chronic Obstructive physiopathology
Reproducibility of Results
Severity of Illness Index
Surveys and Questionnaires
Vital Capacity
Pulmonary Disease, Chronic Obstructive diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 35031681
- Full Text :
- https://doi.org/10.1038/s41598-021-04756-w