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MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 13; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 13. - Publication Year :
- 2022
-
Abstract
- Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field.
- Subjects :
- Animals
Disease Progression
Disease Susceptibility
Humans
Myeloid-Derived Suppressor Cells immunology
Myeloid-Derived Suppressor Cells metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma diagnosis
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma therapy
RNA Interference
T-Lymphocyte Subsets immunology
T-Lymphocyte Subsets metabolism
T-Lymphocyte Subsets pathology
Transcription, Genetic
Tumor Microenvironment genetics
Tumor Microenvironment immunology
Biomarkers, Tumor
Gene Expression Regulation, Leukemic
Immunomodulation genetics
MicroRNAs genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35055013
- Full Text :
- https://doi.org/10.3390/ijms23020829