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Active disease-related compound identification based on capsule network.
- Source :
-
Briefings in bioinformatics [Brief Bioinform] 2022 Jan 17; Vol. 23 (1). - Publication Year :
- 2022
-
Abstract
- Pneumonia, especially corona virus disease 2019 (COVID-19), can lead to serious acute lung injury, acute respiratory distress syndrome, multiple organ failure and even death. Thus it is an urgent task for developing high-efficiency, low-toxicity and targeted drugs according to pathogenesis of coronavirus. In this paper, a novel disease-related compound identification model-based capsule network (CapsNet) is proposed. According to pneumonia-related keywords, the prescriptions and active components related to the pharmacological mechanism of disease are collected and extracted in order to construct training set. The features of each component are extracted as the input layer of capsule network. CapsNet is trained and utilized to identify the pneumonia-related compounds in Qingre Jiedu injection. The experiment results show that CapsNet can identify disease-related compounds more accurately than SVM, RF, gcForest and forgeNet.<br /> (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Details
- Language :
- English
- ISSN :
- 1477-4054
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Briefings in bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 35057581
- Full Text :
- https://doi.org/10.1093/bib/bbab462