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Discovery of 13,15- nor -polycyclic polyprenylated acylphloroglucinols from Hypericum longistylum with anti-inflammatory activity.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Feb 09; Vol. 20 (6), pp. 1284-1291. Date of Electronic Publication: 2022 Feb 09. - Publication Year :
- 2022
-
Abstract
- Spihyperglucinols A (1) and B (2), the first 13,15- nor -polycyclic polyprenylated acylphloroglucinols (PPAPs) featuring a 7/6/5 tricyclic ring system based on an unexpected bicyclo[3.2.2]nonane core, along with three new congeners, spihyperglucinols C-E (3-5), were isolated from Hypericum longistylum . Importantly, 1 and 2 displayed potential inhibitory effects on the production of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with IC <subscript>50</subscript> values of (8.70 ± 1.18) and (9.23 ± 1.26) μM, respectively, comparable to the positive control, dexamethasone, with an IC <subscript>50</subscript> value of (9.76 ± 1.13) μM.
- Subjects :
- Mice
Animals
RAW 264.7 Cells
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents isolation & purification
Drug Discovery
Structure-Activity Relationship
Dose-Response Relationship, Drug
Molecular Structure
Hypericum chemistry
Phloroglucinol pharmacology
Phloroglucinol chemistry
Phloroglucinol isolation & purification
Phloroglucinol analogs & derivatives
Nitric Oxide antagonists & inhibitors
Nitric Oxide biosynthesis
Lipopolysaccharides pharmacology
Lipopolysaccharides antagonists & inhibitors
Macrophages drug effects
Macrophages metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35072672
- Full Text :
- https://doi.org/10.1039/d1ob02107a