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Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention.
- Source :
-
Scientific reports [Sci Rep] 2022 Jan 26; Vol. 12 (1), pp. 1402. Date of Electronic Publication: 2022 Jan 26. - Publication Year :
- 2022
-
Abstract
- Burkina Faso has one of the highest malaria burdens in sub-Saharan Africa despite the mass deployment of insecticide-treated nets (ITNs) and use of seasonal malaria chemoprevention (SMC) in children aged up to 5 years. Identification of risk factors for Plasmodium falciparum infection in rural Burkina Faso could help to identify and target malaria control measures. A cross-sectional survey of 1,199 children and adults was conducted during the peak malaria transmission season in the Cascades Region of south-west Burkina Faso in 2017. Logistic regression was used to identify risk factors for microscopically confirmed P. falciparum infection. A malaria transmission dynamic model was used to determine the impact on malaria cases averted of administering SMC to children aged 5-15 year old. P. falciparum prevalence was 32.8% in the study population. Children aged 5 to < 10 years old were at 3.74 times the odds (95% CI = 2.68-5.22, P < 0.001) and children aged 10 to 15 years old at 3.14 times the odds (95% CI = 1.20-8.21, P = 0.02) of P. falciparum infection compared to children aged less than 5 years old. Administration of SMC to children aged up to 10 years is predicted to avert an additional 57 malaria cases per 1000 population per year (9.4% reduction) and administration to children aged up to 15 years would avert an additional 89 malaria cases per 1000 population per year (14.6% reduction) in the Cascades Region, assuming current coverage of pyrethroid-piperonyl butoxide ITNs. Malaria infections were high in all age strata, although highest in children aged 5 to 15 years, despite roll out of core malaria control interventions. Given the burden of infection in school-age children, extension of the eligibility criteria for SMC could help reduce the burden of malaria in Burkina Faso and other countries in the region.<br /> (© 2022. The Author(s).)
- Subjects :
- Adolescent
Adult
Antigens, Protozoan blood
Antigens, Protozoan immunology
Burkina Faso epidemiology
Child
Child, Preschool
Cross-Sectional Studies
Drug Combinations
Drug Therapy, Combination methods
Female
Humans
Insecticide-Treated Bednets
Malaria, Falciparum blood
Malaria, Falciparum parasitology
Male
Middle Aged
Plasmodium falciparum isolation & purification
Prevalence
Risk Factors
Rural Population
Treatment Outcome
Young Adult
Amodiaquine therapeutic use
Antimalarials therapeutic use
Malaria, Falciparum epidemiology
Malaria, Falciparum prevention & control
Plasmodium falciparum immunology
Pyrimethamine therapeutic use
Seasons
Sulfadoxine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 35082312
- Full Text :
- https://doi.org/10.1038/s41598-022-05056-7