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Strain-release arylations for the bis-functionalization of azetidines.

Authors :
Trauner F
Reiners F
Apaloo-Messan KE
Nißl B
Shahbaz M
Jiang D
Aicher J
Didier D
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Feb 17; Vol. 58 (15), pp. 2564-2567. Date of Electronic Publication: 2022 Feb 17.
Publication Year :
2022

Abstract

The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N -arylation of resulting azetidines, employing either S <subscript>N</subscript> Ar reactions or Buchwald-Hartwig couplings.

Details

Language :
English
ISSN :
1364-548X
Volume :
58
Issue :
15
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
35107096
Full Text :
https://doi.org/10.1039/d1cc07053c