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Strain-release arylations for the bis-functionalization of azetidines.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Feb 17; Vol. 58 (15), pp. 2564-2567. Date of Electronic Publication: 2022 Feb 17. - Publication Year :
- 2022
-
Abstract
- The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N -arylation of resulting azetidines, employing either S <subscript>N</subscript> Ar reactions or Buchwald-Hartwig couplings.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 58
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 35107096
- Full Text :
- https://doi.org/10.1039/d1cc07053c