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The importance of mitochondrial quality control for maintaining skeletal muscle function across health span.
- Source :
-
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2022 Mar 01; Vol. 322 (3), pp. C461-C467. Date of Electronic Publication: 2022 Feb 02. - Publication Year :
- 2022
-
Abstract
- As the principal energy-producing organelles of the cell, mitochondria support numerous biological processes related to metabolism, growth, and regeneration in skeletal muscle. Deterioration in skeletal muscle functional capacity with age is thought to be driven in part by a reduction in skeletal muscle oxidative capacity and reduced fatigue resistance. Underlying this maladaptive response is the development of mitochondrial dysfunction caused by alterations in mitochondrial quality control (MQC), a term encompassing processes of mitochondrial synthesis (biogenesis), remodeling (dynamics), and degradation (mitophagy). Knowledge regarding the role and regulation of MQC in skeletal muscle and the influence of aging in this process has rapidly advanced in the past decade. Given the emerging link between aging and MQC, therapeutic approaches to manipulate MQC to prevent mitochondrial dysfunction during aging hold tremendous therapeutic potential.
Details
- Language :
- English
- ISSN :
- 1522-1563
- Volume :
- 322
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Cell physiology
- Publication Type :
- Academic Journal
- Accession number :
- 35108118
- Full Text :
- https://doi.org/10.1152/ajpcell.00388.2021