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Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2022 Mar; Vol. 42 (3), pp. e74-e84. Date of Electronic Publication: 2022 Feb 03. - Publication Year :
- 2022
-
Abstract
- Clonal expansion is a process that can drive pathogenesis in human diseases, with atherosclerosis being a prominent example. Despite advances in understanding the etiology of atherosclerosis, clonality studies of vascular cells remain in an early stage. Recently, several paradigm-shifting preclinical studies have identified clonal expansion of progenitor cells in the vasculature in response to atherosclerosis. This review provides an overview of cell clonality in atherosclerotic progression, focusing particularly on smooth muscle cells and macrophages. We discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology. The further probing of these mechanisms will provide innovative directions for future progress in the understanding and therapy of atherosclerosis and its associated cardiovascular diseases.
- Subjects :
- Animals
Atherosclerosis etiology
Cell Lineage
Cell Proliferation
Clone Cells pathology
Disease Models, Animal
Humans
Macrophages pathology
Mice
Mice, Transgenic
Plaque, Atherosclerotic etiology
Plaque, Atherosclerotic pathology
Stem Cells pathology
Atherosclerosis pathology
Myocytes, Smooth Muscle pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 35109671
- Full Text :
- https://doi.org/10.1161/ATVBAHA.121.316093