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Air quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g-computation.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Dec; Vol. 18 (12), pp. 2509-2517. Date of Electronic Publication: 2022 Feb 09. - Publication Year :
- 2022
-
Abstract
- Introduction: No evidence exists about the impact of air pollution reduction on incidence of dementia. The aim of this study was to quantify how air quality improvement leads to dementia-incidence benefits.<br />Methods: In the French Three-City cohort (12 years of follow-up), we used parametric g-computation to quantify the expected number of prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 μm (PM <subscript>2.5</subscript> ) reductions.<br />Results: Among 7051 participants, 789 participants developed dementia. The median PM <subscript>2.5</subscript> reduction between 1990 and 2000 was 12.2 (μg/m <superscript>3</superscript> ). Such a reduction reduced the risk of all-cause dementia (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.76 to 0.95). If all study participants were enjoying a hypothetical reduction of more than 13.10 μg/m <superscript>3</superscript> (median reduction observed in the city of Montpellier), the rate difference was -0.37 (95% CI, -0.57 to -0.17) and the rate ratio was 0.67 (95% CI, 0.50 to 0.84).<br />Discussion: These findings highlight the possible substantial benefits of reducing air pollution in the prevention of dementia.<br /> (© 2022 the Alzheimer's Association.)
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 35142029
- Full Text :
- https://doi.org/10.1002/alz.12606