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Pediatric defibrillation shocks alone do not cause heart damage in a porcine model.

Authors :
McCartney B
Harvey A
Kernaghan A
Morais S
McAlister O
Crawford P
Biglarbeigi P
Bond R
Finlay D
McEneaney D
Source :
Resuscitation plus [Resusc Plus] 2022 Feb 01; Vol. 9, pp. 100203. Date of Electronic Publication: 2022 Feb 01 (Print Publication: 2022).
Publication Year :
2022

Abstract

Aim: Automated external defibrillators (AEDs) use various shock protocols with different characteristics when deployed in pediatric mode. The aim of this study is to assess and compare the safety and efficacy of different AED pediatric protocols using novel experimental approaches.<br />Methods: Two defibrillation protocols (A and B) were assessed across two studies: Protocol A: escalating (50-75-90 J) defibrillation waveform with higher voltage, shorter duration and equal phase durations. Protocol B; non-escalating (50-50-50 J) defibrillation waveform with lower voltage, longer duration and unequal phase durations.Experiment 1: Isolated shock damage was assessed following shocks to 12 anesthetized pigs. Animals were randomized into two groups, receiving three shocks from Protocol A (50-75-90 J) or B (50-50-50 J). Cardiac function, cardiac troponin I (cTnI), creatine phosphokinase (CPK) and histopathology were analyzed. Experiment 2: Defibrillation safety and efficacy were assessed through shock success, ROSC, ST-segment deviation and contractility following 16 randomized shocks from protocol A or B delivered to 10 anesthetized pigs in VF.<br />Results: Experiment 1: No clinically meaningful difference in cTnI, CPK, ST-segment deviation, ejection fraction or histopathological damage was observed following defibrillation with either protocol. No difference was observed between protocols at any timepoint. Experiment 2: all defibrillation types demonstrated shock success and ROSC ≥ 97.5%. Post-ROSC contractility was similar between protocols.<br />Conclusions: There is no evidence that administration of clinically relevant shock sequences, without experimental confounders, result in significant myocardial damage in this model of pediatric resuscitation. Typical variations in AED pediatric mode settings do not affect defibrillation safety and efficacy.<br />Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: BM, AH, AK, SM and OM are employed by HeartSine Technologies Ltd., Stryker Belfast. PC is a consultant paid by HeartSine Technologies Ltd., Stryker Belfast. DM sits on the HeartSine Technologies Ltd., Stryker Belfast Clinical Advisory Board and is provided remuneration (modest).<br /> (© 2022 The Author(s).)

Details

Language :
English
ISSN :
2666-5204
Volume :
9
Database :
MEDLINE
Journal :
Resuscitation plus
Publication Type :
Academic Journal
Accession number :
35146463
Full Text :
https://doi.org/10.1016/j.resplu.2022.100203