[Postoperative pancreatitis after pancreatoduodenectomy].

Objective: Retrospective assessment of the influence of postoperative pancreatitis in development of pancreatic fistula.
Material and Methods: The study included 173 patients after pancreatoduodenectomy performed between 2016 and 2019. Postoperative pancreatitis within the 1 ^st postoperative day was verified considering blood amylase > 125 U/L. Patients with postoperative pancreatitis ( n =36) were included in the main group, the control group consisted of 137 patients without pancreatitis. Postoperative pancreatic fistula was determined according to the ISGPS 2016 classification. Statistical analysis of the effect of postoperative pancreatitis on development of pancreatic fistula was carried out using relative risk and odds ratio with 95% confidence interval in both groups.
Results: Postoperative pancreatitis occurred in 36 (20.8%) out of 173 patients after pancreatoduodenectomy. Pancreatic fistula occurred in 18 (50%) cases. Among 137 patients without postoperative pancreatitis, only 18 (13.1%) patients developed severe pancreatic fistula. Relative risk was 3.8 (95% CI 2.22-6.51, p <0.0001), odds ratio - 6.6 (95% CI 2.91-15.01, p <0.0001).
Conclusion: Postoperative pancreatitis significantly influences development of severe pancreatic fistula.