Development of a new method based on gold nanoparticles for determination of uric acid in urine samples.

Authors :: Rezaei H
Jouyban A
Rahimpour E
Source :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2022 May 05; Vol. 272, pp. 120995. Date of Electronic Publication: 2022 Feb 04.
Publication Year :: 2022
Abstract: In the current work, we have reported a fast and easy method based on gold nanoparticles for the determination of uric acid in urine samples. In the first stage, gold nanoparticles were synthesized using the chemical reduction method and then applied as a sensor to measure uric acid concentration based on its strong reducing property. The main parameters affecting response signals such as pH, reagent concentration, and time are optimized using the multivariate method. Under the optimum conditions, the calibration graphs were linear in the range of 0.5 - 10.0 mg.L <superscript>-1</superscript> with limits of detection of 0.2 mg.L <superscript>-1</superscript> and RSD% of 1.2% These results show that this nano-based method is a very sensitive and simple method for the determination of uric acid in urine samples.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2022 Elsevier B.V. All rights reserved.)

Language :: English
ISSN :: 1873-3557
Volume :: 272
Database :: MEDLINE
Journal :: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Publication Type :: Academic Journal
Accession number :: 35152096
Full Text :: https://doi.org/10.1016/j.saa.2022.120995

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