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Optical coherence tomography-guided confocal Raman microspectroscopy for rapid measurements in tissues.
- Source :
-
Biomedical optics express [Biomed Opt Express] 2021 Dec 14; Vol. 13 (1), pp. 344-357. Date of Electronic Publication: 2021 Dec 14 (Print Publication: 2022). - Publication Year :
- 2021
-
Abstract
- We report a joint system with both confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) modules capable of quickly addressing the region of interest in a tissue for targeted Raman measurements from OCT. By using an electrically tunable lens in the Raman module, the focus of the module can be adjusted to address any specific depth indicated in an OCT image in a few milliseconds. We demonstrate the performance of the joint system in the depth dependent measurements of an ex vivo swine tissue and in vivo human skin. This system can be useful in measuring samples embedded with small targets, for example, to identify tumors in skin in vivo and assessment of tumor margins, in which OCT can be used to perform initial real-time screening with high throughput based on morphological features to identify suspicious targets then CRS is guided to address the targets in real time and fully characterize their biochemical fingerprints for confirmation.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)
Details
- Language :
- English
- ISSN :
- 2156-7085
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomedical optics express
- Publication Type :
- Academic Journal
- Accession number :
- 35154875
- Full Text :
- https://doi.org/10.1364/BOE.441058