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Short-Term Immune Responses of Gilthead Seabream ( Sparus aurata ) Juveniles against Photobacterium damselae subsp. piscicida .
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 29; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 29. - Publication Year :
- 2022
-
Abstract
- Photobacteriosis is a septicaemic bacterial disease affecting several marine species around the globe, resulting in significant economic losses. Although many studies have been performed related to the pathogen virulence and resistance factors, information regarding the host defence mechanisms activated once an infection takes place is still scarce. The present study was designed to understand innate immune responses of farmed juvenile gilthead seabream ( Sparus aurata ) after Photobacterium damselae subsp. piscicida ( Phdp ) infection. Therefore, two groups of seabream juveniles were intraperitoneally injected with 100 µL of PBS (placebo) or 100 µL of exponentially growing Phdp (1 × 10 <superscript>6</superscript> CFU/mL; infected). The blood, plasma, liver, and head kidney of six fish from each treatment were sampled immediately before infection and 3, 6, 9, 24 and 48 h after infection for the broad screening of fish immune and oxidative stress responses. Infected animals presented marked anaemia, neutrophilia and monocytosis, conditions that are correlated with an increased expression of genes related to inflammation and phagocytic activity. Similar studies with different fish species and bacteria can be useful for the definition of health biomarkers that might help fish farmers to prevent the occurrence of such diseases.
- Subjects :
- Animals
Blood Cells metabolism
Fish Proteins genetics
Fish Proteins metabolism
Gene Expression Regulation
Head Kidney metabolism
Immunity, Humoral genetics
Immunity, Innate genetics
Oxidative Stress genetics
Sea Bream blood
Sea Bream genetics
Immunity
Photobacterium physiology
Sea Bream immunology
Sea Bream microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35163486
- Full Text :
- https://doi.org/10.3390/ijms23031561