Meropenem to Treat Valproic Acid Intoxication.

Authors :: Smolders EJ
Ter Heine R
Natsch S
Kramers K
Source :: Therapeutic drug monitoring [Ther Drug Monit] 2022 Jun 01; Vol. 44 (3), pp. 359-362.
Publication Year :: 2022
Abstract: Abstract: This therapeutic drug monitoring (TDM) grand round describes a patient with serious valproic acid intoxication. A total valproic acid level of 844 mg/L and an unbound valproic acid level of 604 mg/L were observed. Meropenem was administered to enhance the clearance of valproic acid. This off-label usage of meropenem is based on the drug-drug interaction between carbapenems and valproic acid, which reduced the level of valproic acid within 24 hours after administration.<br /> (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)