The influence of PM 2.5 exposure on kidney diseases.

Authors :: Xu W
Wang S
Jiang L
Sun X
Wang N
Liu X
Yao X
Qiu T
Zhang C
Li J
Deng H
Yang G
Source :: Human & experimental toxicology [Hum Exp Toxicol] 2022 Jan-Dec; Vol. 41, pp. 9603271211069982.
Publication Year :: 2022
Abstract: The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM <subscript>2.5</subscript> ). In recent years, epidemiological investigations have confirmed that PM <subscript>2.5</subscript> is closely related to chronic kidney disease and membranous nephropathy Basic research has demonstrated that PM <subscript>2.5</subscript> has an impact on the normal function of the kidneys through accumulation in the kidney, endothelial dysfunction, abnormal renin-angiotensin system, and immune complex deposition. Moreover, the mechanism of PM <subscript>2.5</subscript> damage to the kidney involves inflammation, oxidative stress, apoptosis, DNA damage, and autophagy. In this review, we summarized the latest developments in the effects of PM <subscript>2.5</subscript> on kidney disease in human and animal studies, so as to provide new ideas for the prevention and treatment of kidney disease.