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Cannabidiol, a Regulator of Intracellular Calcium and Calpain.

Authors :
Jeon KH
Park SH
Bae WJ
Kim SW
Park HJ
Kim S
Kim TH
Jeon SH
Park I
Park HJ
Kwon Y
Source :
Cannabis and cannabinoid research [Cannabis Cannabinoid Res] 2023 Feb; Vol. 8 (1), pp. 119-125. Date of Electronic Publication: 2022 Feb 22.
Publication Year :
2023

Abstract

Cannabidiol (CBD) is one of the most abundant components of Cannabis and has long been used in Cannabis-based preparations. Recently, CBD has become a promising pharmacological agent because of its beneficial properties in the pathophysiology of several diseases. Although CBD is a kind of cannabinoid and acts on cannabinoid receptors (CB1 and CB2), molecular targets involved in diverse therapeutic properties of CBD have not been identified because CBD also interacts with other molecular targets. Considering that CBD alters the intracellular calcium level by which calpain activity is controlled, and both CBD and calpain are associated with various diseases related to calcium signaling, including neurological disorders, this review provides an overview of calpain and calcium signaling as possible molecular targets of CBD. As calpain is known to play an important role in the pathophysiology of neurological disease, a deeper understanding of its relationship with CBD will be meaningful. To understand the role of CBD as a calpain regulator, in silico structural analysis on the binding mode of CBD with calpain was performed.

Details

Language :
English
ISSN :
2378-8763
Volume :
8
Issue :
1
Database :
MEDLINE
Journal :
Cannabis and cannabinoid research
Publication Type :
Academic Journal
Accession number :
35196129
Full Text :
https://doi.org/10.1089/can.2021.0197