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The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication.
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication.
- Source :
-
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2022 Feb 23; Vol. 7 (1), pp. 57. Date of Electronic Publication: 2022 Feb 23. - Publication Year :
- 2022
-
Abstract
- The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.<br /> (© 2022. The Author(s).)
- Subjects :
- Acute Kidney Injury drug therapy
Acute Kidney Injury immunology
Acute Kidney Injury virology
Anticoagulants therapeutic use
Antiviral Agents therapeutic use
COVID-19 immunology
COVID-19 virology
Clinical Trials as Topic
Cytokine Release Syndrome drug therapy
Cytokine Release Syndrome immunology
Cytokine Release Syndrome virology
Disseminated Intravascular Coagulation drug therapy
Disseminated Intravascular Coagulation immunology
Disseminated Intravascular Coagulation virology
Endothelial Cells drug effects
Endothelial Cells immunology
Endothelial Cells virology
Humans
Immunity, Innate drug effects
Immunologic Factors therapeutic use
Lymphopenia drug therapy
Lymphopenia immunology
Lymphopenia virology
Myocarditis drug therapy
Myocarditis immunology
Myocarditis virology
Pulmonary Embolism drug therapy
Pulmonary Embolism immunology
Pulmonary Embolism virology
Renin-Angiotensin System drug effects
Renin-Angiotensin System immunology
SARS-CoV-2 drug effects
SARS-CoV-2 growth & development
SARS-CoV-2 pathogenicity
COVID-19 Drug Treatment
Acute Kidney Injury complications
COVID-19 complications
Cytokine Release Syndrome complications
Disseminated Intravascular Coagulation complications
Lymphopenia complications
Myocarditis complications
Pulmonary Embolism complications
Subjects
Details
- Language :
- English
- ISSN :
- 2059-3635
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Signal transduction and targeted therapy
- Publication Type :
- Academic Journal
- Accession number :
- 35197452
- Full Text :
- https://doi.org/10.1038/s41392-022-00907-1