Back to Search
Start Over
Effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants: a Meta analysis.
- Source :
-
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2022 Feb 15; Vol. 24 (2), pp. 169-175. - Publication Year :
- 2022
-
Abstract
- Objectives: To systematically evaluate the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical development in preterm infants.<br />Methods: A computerized search was performed in the databases including China National Knowledge Infrastructure, Wanfang Data, Weipu, PubMed, Embase, and the Cochrane Library to identify randomized controlled trials of the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants. RevMan 5.3 software was used to perform a Meta analysis for the included studies.<br />Results: A total of 7 randomized controlled studies were included. The results of Meta analysis showed that compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula could reduce the risk of neonatal necrotizing enterocolitis ( RR =0.40, P =0.04) and feeding intolerance ( RR =0.40, P =0.005), and had no significant effect on the growth of weight, length and head circumference ( P >0.05).<br />Conclusions: Compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula in preterm infants may reduce the occurrence of necrotizing enterocolitis and feeding intolerance, and can meet the nutrient requirement of physical development. However, the evidence is limited, and the results of this study cannot support the routine prophylactic use of hydrolyzed protein formula in preterm infants.
- Subjects :
- Humans
Infant
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Randomized Controlled Trials as Topic
Enterocolitis, Necrotizing epidemiology
Enterocolitis, Necrotizing prevention & control
Gastrointestinal Diseases epidemiology
Gastrointestinal Diseases prevention & control
Infant Formula chemistry
Subjects
Details
- Language :
- English; Chinese
- ISSN :
- 1008-8830
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 35209982
- Full Text :
- https://doi.org/10.7499/j.issn.1008-8830.2109124