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Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women.

Authors :
De Jong KA
Berisha F
Naderpoor N
Appelbe A
Kotowicz MA
Cukier K
McGee SL
Nikolaev VO
Source :
PloS one [PLoS One] 2022 Feb 25; Vol. 17 (2), pp. e0263312. Date of Electronic Publication: 2022 Feb 25 (Print Publication: 2022).
Publication Year :
2022

Abstract

Background: It remains unclear as to whether polycystic ovary syndrome (PCOS) is an additional risk factor in the development of left ventricular (LV) hypertrophy in obese women. In the current study, we provide clarity on this issue by rigorously analysing patient LV geometry beyond the basic clinical measures currently used. Importantly, the cohort contained only normotensive patients that would normally be deemed low risk with no further intervention required.<br />Methods: The study comprised 24 obese women with PCOS and 29 obese Control women. Transthoracic echocardiography was used to evaluate LV structure/function. Basic clinical and metabolic data were collected for each participant consisting of age, BMI, blood pressure, fasting glucose, LDL-C, HLD-C, cholesterol and triglyceride levels. Exclusion criteria; BMI < 30 g/m2, type 2 diabetes, hypertension.<br />Results: Both groups exhibited concentric remodelling of the LV posterior wall at a prevalence of ~20%, this associated with grade 1 diastolic dysfunction. Estimated LV mass/height2.7 was increased patients with PCOS (45 ± 2.2 vs 37 ± 1.6) with 33% exhibiting LV mass/height2.7 above ASE guidelines, compared to 7% in Controls. Furthermore, 25% of patients with PCOS were characterised with concentric hypertrophy, an alteration in LV geometry that was not observed in the Control group.<br />Conclusions: To our knowledge, this is the first study to assess LV geometric patterns in obese women with PCOS. The results suggest that obese women with PCOS are at greater risk of concentric hypertrophy than obese only women and provide justification for additional cardiovascular risk assessment in normotensive obese/PCOS women.<br />Competing Interests: he authors have declared that no competing interests exist.

Details

Language :
English
ISSN :
1932-6203
Volume :
17
Issue :
2
Database :
MEDLINE
Journal :
PloS one
Publication Type :
Academic Journal
Accession number :
35213570
Full Text :
https://doi.org/10.1371/journal.pone.0263312