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Adverse reactions of ALA-PDT for the treatment of cutaneous diseases: A retrospective study.
- Source :
-
Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2022 Jun; Vol. 38, pp. 102783. Date of Electronic Publication: 2022 Feb 24. - Publication Year :
- 2022
-
Abstract
- Background: 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective therapy for cutaneous diseases, such as precancers, superficial non melanoma skin cancers and certain inflammatory or viral conditions. However, the absence of a complete picture of adverse reactions limits the promotion of ALA-PDT.<br />Objective: To systemically investigate the detailed evidence of adverse reactions relating to ALA-PDT for skin diseases.<br />Methods: A retrospective study performed at the Shanghai Skin Disease Hospital.<br />Results: In the retrospective study, 439 patients were included. Incidences of adverse reactions, including in-treatment pain (98.8%), erythema (92.4%), edema (35.0%), exudation (23.0%), hyperpigmentation (27.3%) were clarified. Edema was more common in female patients (P<0.05). Patients with HPV-related skin diseases were more likely to suffer erythema, edema or exudation (P<0.05). Hyperpigmentation was more likely to occur in skin appendage disorders (P<0.05). Fever (2.4%) and hypopigmentation (1.9%) are two neglected adverse reactions analyzed in detail. Fever is more prevalent in female patients. Hypopigmentation occurred predominantly in elderly with skin cancer or precancerosis lesions.<br />Conclusion: The results outline detailed information about the adverse reactions, including systemic reactions following ALA-PDT, assisting dermatologists in predicting and managing adverse reactions for greater efficacy and higher patient satisfaction.<br /> (Copyright © 2022. Published by Elsevier B.V.)
- Subjects :
- Aged
Aminolevulinic Acid adverse effects
China
Erythema chemically induced
Erythema drug therapy
Female
Humans
Photosensitizing Agents adverse effects
Retrospective Studies
Hyperpigmentation chemically induced
Hyperpigmentation drug therapy
Hypopigmentation chemically induced
Hypopigmentation drug therapy
Photochemotherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1597
- Volume :
- 38
- Database :
- MEDLINE
- Journal :
- Photodiagnosis and photodynamic therapy
- Publication Type :
- Academic Journal
- Accession number :
- 35218941
- Full Text :
- https://doi.org/10.1016/j.pdpdt.2022.102783