Back to Search
Start Over
Influenza immunization in systemic lupus eruthematosus. A double-blind trial.
- Source :
-
Annals of internal medicine [Ann Intern Med] 1978 Jun; Vol. 88 (6), pp. 729-34. - Publication Year :
- 1978
-
Abstract
- Forty patients with systemic lupus erythematosus randomly received inactivated bivalent (A/NJ and A/Victoria) influenza vaccine or saline in a double-blind study. During 20 weeks of follow-up, no deterioration in major organ function or increase in disease flares was observed in the immunized group as compared with the group that received saline. Preimmunization antibody titers to A/Victoria were lower in the 40 patients with lupus erythematosus than in age-matched control subjects. Response to immunization, as measured by serum antibody titers, was also lower in the patients with lupus erythematosus, indicating that immune responses must be evaluated on an individual patient basis. Nevertheless, influenza vaccination can be safely carried out in patients with systemic lupus erythematosus.
- Subjects :
- Adult
Antibodies, Viral analysis
Antibody Formation drug effects
Clinical Trials as Topic
Complement C3 metabolism
DNA metabolism
Double-Blind Method
Female
Hemagglutination Inhibition Tests
Humans
Immunosuppressive Agents pharmacology
Male
Prednisone pharmacology
Recurrence
Influenza Vaccines adverse effects
Influenza, Human prevention & control
Lupus Erythematosus, Systemic immunology
Vaccination adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4819
- Volume :
- 88
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 352210
- Full Text :
- https://doi.org/10.7326/0003-4819-88-6-729