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Further developments of β,γ -unsaturated α -ketoesters as versatile synthons in asymmetric catalysis.
- Source :
-
IScience [iScience] 2022 Feb 11; Vol. 25 (3), pp. 103913. Date of Electronic Publication: 2022 Feb 11 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- β,γ -Unsaturated α -ketoesters prove to be versatile organic synthons participating in diverse catalytic asymmetric transformations with the breathtaking development of organo-catalysis, new catalytic systems including ingenious chiral ligands as well as Lewis acid cations. The highly efficient creation of stereogenic centers with excellent enantioselectivity is not a surprise, but owes to the bidentate coordination of its unique 1,2-dicarbonyl motif to artful chiral messenger, establishing a rigid system for the precise chiral-identification of the attack. In the past five years, various reaction modes of β,γ -unsaturated α -ketoesters have been developed, involving their multiple reaction sites, such as the carbon-carbon double bond (C=C), the carbonyl group (C=O), the entire C=C-C=O fragment, and the ester group. In this review, we summarize the state-of-the-art catalytic asymmetric reactions of β,γ -unsaturated α -ketoesters, to provide an updated overview to chemists working in this and related fields, facilitating their discoveries in asymmetric catalysis, natural products synthesis, and drug development.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2022 The Author(s).)
Details
- Language :
- English
- ISSN :
- 2589-0042
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- IScience
- Publication Type :
- Academic Journal
- Accession number :
- 35243262
- Full Text :
- https://doi.org/10.1016/j.isci.2022.103913