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Merging C-C σ-bond activation of cyclobutanones with CO 2 fixation via Ni-catalysis.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Mar 24; Vol. 58 (25), pp. 4071-4074. Date of Electronic Publication: 2022 Mar 24. - Publication Year :
- 2022
-
Abstract
- A carboxylative Ni-catalyzed tandem C-C σ-bond activation of cyclobutanones followed by CO <subscript>2</subscript> -electrophilic trapping is documented as a direct route to synthetically valuable 3-indanone-1-acetic acids. The protocol shows an adequate functional group tolerance and useful chemical outcomes (yield up to 76%) when AlCl <subscript>3</subscript> is adopted as an additive. Manipulations of the targeted cyclic scaffolds and a mechanistic proposal based on experimental evidence complete the investigation.
- Subjects :
- Catalysis
Carbon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 58
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 35262541
- Full Text :
- https://doi.org/10.1039/d2cc00149g