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Pharmaceutical Development and Design of Thermosensitive Liposomes Based on the QbD Approach.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 24; Vol. 27 (5). Date of Electronic Publication: 2022 Feb 24. - Publication Year :
- 2022
-
Abstract
- This study aimed to produce thermosensitive liposomes (TSL) by applying the quality by design (QbD) concept. In this paper, our research group collected and studied the parameters that significantly impact the quality of the liposomal product. Thermosensitive liposomes are vesicles used as drug delivery systems that release the active pharmaceutical ingredient in a targeted way at ~40-42 °C, i.e., in local hyperthermia. This study aimed to manufacture thermosensitive liposomes with a diameter of approximately 100 nm. The first TSLs were made from DPPC (1,2-dipalmitoyl-sn-glycerol-3-phosphocholine) and DSPC (1,2-dioctadecanoyl-sn-glycero-3-phosphocholine) phospholipids. Studies showed that the application of different types and ratios of lipids influences the thermal properties of liposomes. In this research, we made thermosensitive liposomes using a PEGylated lipid besides the previously mentioned phospholipids with the thin-film hydration method.
- Subjects :
- Drug Delivery Systems
Drug Development
Temperature
Liposomes
Phospholipids
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 35268637
- Full Text :
- https://doi.org/10.3390/molecules27051536