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Thyroid dysfunction incidence and risk factors in Chinese chronic hepatitis B patients treated with pegylated interferon alpha: A long-term follow-up study.
- Source :
-
Journal of viral hepatitis [J Viral Hepat] 2022 Jun; Vol. 29 (6), pp. 412-419. Date of Electronic Publication: 2022 Apr 09. - Publication Year :
- 2022
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Abstract
- The long-term impact, incidence and risk factors of thyroid dysfunction in chronic hepatitis B (CHB) patients receiving pegylated interferon (IFN) alpha (PegIFN-alpha) therapy remain unclear. We aim to investigate the long-term safety of thyroid dysfunction in CHB patients receiving PegIFN-alpha. A retrospective observational study of 425 CHB patients with normal baseline thyroid function was carried out. Patients were followed up over 10 years to assess thyroid function after receiving IFN. At the end of the IFN therapy, 67 patients (15.8%) had developed thyroid dysfunction, 31 patients (46.3%) had hyperthyroidism and 64.4% presented with subclinical thyroid dysfunction. In follow-up of thyroid dysfunction patients, 37 patients (74.0%) spontaneously regained normal thyroid function. Pretreatment thyroid-stimulating hormone (TSH) level, thyroid peroxidase antibody (TPOAb) positivity and free thyroxine (FT4) were independent risk factors associated with thyroid dysfunction incidence. High TSH level (OR = 9.866, 95%CI, 3.245-29.998) was associated with a greater likelihood of hypothyroidism. High FT4 levels (OR = 0.464, 95%CI, 0.248-0.868) indicate a low likelihood of thyroid dysfunction. Thyroid dysfunction is a common but acceptable side effect of IFN therapy for CHB. Most thyroid dysfunction is reversible. Pretreatment TSH level and TPOAb positivity are risk factors for thyroid dysfunction development during IFN therapy. A high TSH level predicts an increased incidence of hypothyroidism. Moreover, FT4 may be a protective factor for thyroid dysfunction.<br /> (© 2022 John Wiley & Sons Ltd.)
- Subjects :
- China epidemiology
Follow-Up Studies
Humans
Incidence
Interferon-alpha adverse effects
Polyethylene Glycols adverse effects
Risk Factors
Thyrotropin
Hepatitis B, Chronic drug therapy
Hypothyroidism chemically induced
Hypothyroidism drug therapy
Thyroid Diseases chemically induced
Thyroid Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2893
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of viral hepatitis
- Publication Type :
- Academic Journal
- Accession number :
- 35293082
- Full Text :
- https://doi.org/10.1111/jvh.13667