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Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells.
- Source :
-
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Mar 11; Vol. 2022, pp. 4978556. Date of Electronic Publication: 2022 Mar 11 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa ( P.a. ) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS-induced mortality and the production of inflammatory mediators IL-6, TNF- α , MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNF κ B cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS-stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF- κ B activation and inducing Nrf2-mediated HO-1 expression.<br />Competing Interests: The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article.<br /> (Copyright © 2022 Hui-Wen Lin et al.)
- Subjects :
- Animals
Heme Oxygenase-1 metabolism
Janus Kinase 1
Lipopolysaccharides pharmacology
Mice
Microglia metabolism
NF-E2-Related Factor 2 metabolism
Nitric Oxide metabolism
Pseudomonas aeruginosa
Curcumin analogs & derivatives
Curcumin metabolism
Curcumin pharmacology
Inflammation chemically induced
Inflammation drug therapy
Inflammation metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2022
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 35308172
- Full Text :
- https://doi.org/10.1155/2022/4978556