Back to Search
Start Over
A comparison of piperacillin, cephalothin and cefoxitin in the prevention of postoperative infections in patients undergoing vaginal hysterectomy.
- Source :
-
Surgery, gynecology & obstetrics [Surg Gynecol Obstet] 1986 Nov; Vol. 163 (5), pp. 421-7. - Publication Year :
- 1986
-
Abstract
- A randomized, double-blind, multicenter trial was initiated to compare the safety and efficacy of piperacillin, cephalothin and cefoxitin in the prophylactic treatment of patients undergoing vaginal hysterectomy. The total dose of each antibiotic was 6 grams given in three equally divided doses. A satisfactory prophylactic response was obtained in 143 of 151 (95 per cent) patients treated with piperacillin, in 82 of 87 (94 per cent) patients treated with cephalothin and in 57 of 60 (95 per cent) patients treated with cefoxitin. The pooled data indicated that the piperacillin treatment group did not differ from the combined cephalosporin treatment groups with respect to prophylactic response, presence of febrile morbidity, fever index, duration of postoperative hospitalization and incidence of reported adverse experiences.
- Subjects :
- Adult
Aged
Aged, 80 and over
Cefoxitin administration & dosage
Cephalothin administration & dosage
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Microbial Sensitivity Tests
Middle Aged
Piperacillin administration & dosage
Random Allocation
Bacterial Infections prevention & control
Cefoxitin therapeutic use
Cephalothin therapeutic use
Hysterectomy
Hysterectomy, Vaginal
Piperacillin therapeutic use
Postoperative Complications prevention & control
Premedication
Subjects
Details
- Language :
- English
- ISSN :
- 0039-6087
- Volume :
- 163
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Surgery, gynecology & obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 3535134