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SARS-CoV-2-specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID-19 vaccination.

Authors :
Jarisch A
Wiercinska E
Daqiq-Mirdad S
Hellstern H
Ajib S
Cremer A
Nguyen NTT
Dukat A
Ullrich E
Ciesek S
Chow KU
Serve H
Seifried E
Bader P
Bonig H
Bug G
Source :
European journal of immunology [Eur J Immunol] 2022 Jul; Vol. 52 (7), pp. 1194-1197. Date of Electronic Publication: 2022 Apr 28.
Publication Year :
2022

Abstract

Little is known about the cellular immune response to SARS-CoV-2 vaccination in patients after HSCT and B-NHL with iatrogenic B-cell aplasia. In nonseroconverted HSCT patients, induction of specific T-cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses to vaccination also fail to mount antigen-specific T-cell responses.<br /> (© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)

Details

Language :
English
ISSN :
1521-4141
Volume :
52
Issue :
7
Database :
MEDLINE
Journal :
European journal of immunology
Publication Type :
Academic Journal
Accession number :
35389515
Full Text :
https://doi.org/10.1002/eji.202149771