Back to Search
Start Over
Prediction of treatment outcome in neovascular age-related macular degeneration using a novel convolutional neural network.
- Source :
-
Scientific reports [Sci Rep] 2022 Apr 07; Vol. 12 (1), pp. 5871. Date of Electronic Publication: 2022 Apr 07. - Publication Year :
- 2022
-
Abstract
- While prognosis and risk of progression are crucial in developing precise therapeutic strategy in neovascular age-related macular degeneration (nAMD), limited predictive tools are available. We proposed a novel deep convolutional neural network that enables feature extraction through image and non-image data integration to seize imperative information and achieve highly accurate outcome prediction. The Heterogeneous Data Fusion Net (HDF-Net) was designed to predict visual acuity (VA) outcome (improvement ≥ 2 line or not) at 12th months after anti-VEGF treatment. A set of pre-treatment optical coherence tomography (OCT) image and non-image demographic features were employed as input data and the corresponding 12th-month post-treatment VA as the target data to train, validate, and test the HDF-Net. This newly designed HDF-Net demonstrated an AUC of 0.989 (95% CI 0.970-0.999), accuracy of 0.936 [95% confidence interval (CI) 0.889-0.964], sensitivity of 0.933 (95% CI 0.841-0.974), and specificity of 0.938 (95% CI 0.877-0.969). By simulating the clinical decision process with mixed pre-treatment information from raw OCT images and numeric data, HDF-Net demonstrated promising performance in predicting individualized treatment outcome. The results highlight the potential of deep learning to simultaneously process a broad range of clinical data to weigh and leverage the complete information of the patient. This novel approach is an important step toward real-world personalized therapeutic strategy for typical nAMD.<br /> (© 2022. The Author(s).)
- Subjects :
- Angiogenesis Inhibitors therapeutic use
Humans
Intravitreal Injections
Neural Networks, Computer
Retrospective Studies
Tomography, Optical Coherence methods
Treatment Outcome
Visual Acuity
Macular Degeneration diagnostic imaging
Macular Degeneration drug therapy
Wet Macular Degeneration diagnostic imaging
Wet Macular Degeneration drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 35393449
- Full Text :
- https://doi.org/10.1038/s41598-022-09642-7