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Modified Proline Metabolism and Prolidase Enzyme in COVID-19.

Authors :: Ergin Tuncay M
Neselioglu S
Asfuroglu Kalkan E
Inan O
Sena Akkus M
Ates I
Erel O
Source :: Laboratory medicine [Lab Med] 2022 Sep 01; Vol. 53 (5), pp. 453-458.
Publication Year :: 2022
Abstract: Objective: The aim of the study was to evaluate proline metabolism in patients affected by COVID-19.<br />Materials and Methods: This case-control study consisted of 116 patients with COVID-19 and 46 healthy individuals. Tests related to proline metabolism (prolidase, proline, hydroxyproline, glutamic acid, manganese) and copper and zinc tests were analyzed.<br />Results: The levels of proline and hydroxyproline amino acids and the prolidase enzyme were found to be lower and glutamic acid was found to be higher in the COVID-19 group compared to the healthy group (P = .012, P < .001, P < .001, and P < .001, respectively). The copper/zinc ratio was higher in patients with COVID-19 than in healthy individuals (P < .001). Significant correlations were found between proline metabolism tests and inflammatory and hemostatic markers commonly used in COVID-19.<br />Conclusion: The proline metabolic pathway was affected in COVID-19. Relationships between proline pathway-related tests and inflammatory/hemostatic markers supported the roles of proline metabolism in proinflammatory and immune response processes.<br /> (© The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)