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MDS/AML with del5q: An acquired "laminopathy"?
- Source :
-
Cell stem cell [Cell Stem Cell] 2022 Apr 07; Vol. 29 (4), pp. 498-499. - Publication Year :
- 2022
-
Abstract
- In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause of HSPC fate alterations promoting malignancy.<br />Competing Interests: Declaration of interests The author declares no competing interests.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1875-9777
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cell stem cell
- Publication Type :
- Academic Journal
- Accession number :
- 35395184
- Full Text :
- https://doi.org/10.1016/j.stem.2022.03.008