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Copper(I)-Catalyzed Formation of Isoquinoline and Quinoline Substituted Isobenzofurans.
- Source :
-
Organic letters [Org Lett] 2022 Apr 22; Vol. 24 (15), pp. 2899-2904. Date of Electronic Publication: 2022 Apr 11. - Publication Year :
- 2022
-
Abstract
- An efficient synthetic organic transformation was developed to access isoquinoline-substituted isobenzofurans by reaction of substituted 1,5-diynes with isoquinoline N -oxides. Moderate to excellent yields of isoquinoline-derived isobenzofurans were achieved by formation of a new C-C and two C-O bonds in the presence of copper catalyst in one pot. whereas quinoline-substituted isobenzofurans were obtained when the reaction was conducted using quinoline N -oxides and 1,5-diynes in the presence copper catalyst.
- Subjects :
- Catalysis
Isoquinolines
Oxides chemistry
Quinolines
Copper chemistry
Diynes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 24
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 35404065
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c00864