The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders.

Authors :: Lu X
Ding Y
Liu H
Sun M
Chen C
Yang Y
Wang H
Source :: International journal of molecular sciences [Int J Mol Sci] 2022 Apr 06; Vol. 23 (7). Date of Electronic Publication: 2022 Apr 06.
Publication Year :: 2022
Abstract: Autophagy is a complex process of degradation of senescent or dysfunctional organelles in cells. Dysfunctional autophagy is associated with many diseases such as cancers, immune dysfunction, and aging. Hydrogen sulfide (H <subscript>2</subscript> S) is considered to be the third gas signal molecule after nitrous oxide and carbon monoxide. In recent years, H <subscript>2</subscript> S has been found to have a variety of important biological functions, and plays an important role in a variety of physiological and pathological processes. In this review, we review the recent role and mechanism of H <subscript>2</subscript> S in regulating autophagy in liver disorders, in order to provide a basis for further research in the future.