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Effect of Riluzole on the Expression of HCN2 in Dorsal Root Ganglion Neurons of Diabetic Neuropathic Pain Rats.
- Source :
-
Journal of healthcare engineering [J Healthc Eng] 2022 Apr 06; Vol. 2022, pp. 8313415. Date of Electronic Publication: 2022 Apr 06 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Neuropathic pain since early diabetes swamps patients' lives, and diabetes mellitus has become an increasingly worldwide epidemic. No agent, so far, can terminate the ongoing diabetes. Therefore, strategies that delay the process and the further complications are preferred, such as diabetic neuropathic pain (DNP). Dysfunction of ion channels is generally accepted as the central mechanism of diabetic associated neuropathy, of which hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channel has been verified the involvement of neuropathic pain in dorsal root ganglion (DRG) neurons. Riluzole is a benzothiazole compound with neuroprotective properties on intervention to various ion channels, including hyperpolarization-activated voltage-dependent channels. To investigate the effect of riluzole within lumbar (L3-5) DRG neurons from DNP models, streptozocin (STZ, 70 mg/kg) injection was recruited subcutaneously followed by paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL), which both show significant reduction, whilst relieved by riluzole (4 mg/kg/d) administration, which was performed once daily for 7 consecutive days for 14 days. HCN2 expression was also decreased in line with alleviated behavioral tests. Our results indicate riluzole as the alleviator to STZ-induced DNP with involvement of downregulated HCN2 in lumbar DRG by continual systemic administration in rats.<br />Competing Interests: The authors declare that they have no conflicts of interest.<br /> (Copyright © 2022 Dong-mei Zhou et al.)
- Subjects :
- Animals
Ganglia, Spinal metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels metabolism
Neurons
Nucleotides, Cyclic metabolism
Nucleotides, Cyclic pharmacology
Potassium Channels metabolism
Potassium Channels pharmacology
Rats
Riluzole metabolism
Riluzole pharmacology
Riluzole therapeutic use
Streptozocin metabolism
Streptozocin pharmacology
Diabetes Mellitus
Diabetic Neuropathies complications
Diabetic Neuropathies drug therapy
Diabetic Neuropathies metabolism
Neuralgia complications
Neuralgia drug therapy
Neuralgia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2040-2309
- Volume :
- 2022
- Database :
- MEDLINE
- Journal :
- Journal of healthcare engineering
- Publication Type :
- Academic Journal
- Accession number :
- 35432830
- Full Text :
- https://doi.org/10.1155/2022/8313415