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Specification of CNS macrophage subsets occurs postnatally in defined niches.
- Source :
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Nature [Nature] 2022 Apr; Vol. 604 (7907), pp. 740-748. Date of Electronic Publication: 2022 Apr 20. - Publication Year :
- 2022
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Abstract
- All tissue-resident macrophages of the central nervous system (CNS)-including parenchymal microglia, as well as CNS-associated macrophages (CAMs <superscript>1</superscript> ) such as meningeal and perivascular macrophages <superscript>2-7</superscript> -are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma <superscript>2,8-10</superscript> . It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors <superscript>11-15</superscript> . However, the precise ontogenetic relationships, the underlying transcriptional programs and the molecular signals that drive the development of distinct CAM subsets in situ are poorly understood. Here we show, using fate-mapping systems, single-cell profiling and cell-specific mutants, that only meningeal macrophages and microglia share a common prenatal progenitor. By contrast, perivascular macrophages originate from perinatal meningeal macrophages only after birth in an integrin-dependent manner. The establishment of perivascular macrophages critically requires the presence of arterial vascular smooth muscle cells. Together, our data reveal a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the CNS.<br /> (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 604
- Issue :
- 7907
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 35444273
- Full Text :
- https://doi.org/10.1038/s41586-022-04596-2