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Polypyrrole Cubosomes with Ordered Ultralarge Mesopore for Controllable Encapsulation and Release of Albumin.

Polypyrrole Cubosomes with Ordered Ultralarge Mesopore for Controllable Encapsulation and Release of Albumin.

Authors :
Wu Y
Cui J
Ling Y
Wang X
Fu J
Jing C
Cheng J
Ma Y
Liu J
Liu S
Source :
Nano letters [Nano Lett] 2022 May 11; Vol. 22 (9), pp. 3685-3690. Date of Electronic Publication: 2022 Apr 21.
Publication Year :
2022

Abstract

Despite substantial progress in porous materials over past years, controllable preparation of conductive polymers (CPs) with continuous large pores is challenging, which are important for diverse applications, including energy storage, electrocatalysis, and biological separations. Here, we develop an unprecedented ordered bicontinuous mesoporous PPy cubosomes (mPPy-cs) using a soft-template strategy, resulting in ultralarge pores of ∼45 nm and high specific surface area of 69.5 m <superscript>2</superscript> g <superscript>-1</superscript> . Along with their unique characteristics of adjustable surface charges and sensitivity to pH, mPPy-cs exhibited a near quantitative adsorption of albumin within 30 min, enabling efficient separation from immunoglobulin G, a typical inclusion in commercial albumin products. Moreover, the absorbed albumin could be further released in a controlled manner by lowering the pH. This work provides a feasible strategy for bottom-up construction of CPs with tailored pore sizes and nanoarchitectures, expected to attract significant attention to their properties and applications.

Details

Language :
English
ISSN :
1530-6992
Volume :
22
Issue :
9
Database :
MEDLINE
Journal :
Nano letters
Publication Type :
Academic Journal
Accession number :
35446565
Full Text :
https://doi.org/10.1021/acs.nanolett.2c00330